Rapid degradation of Streptococcus pyogenes biofilms by PlyC, a bacteriophage-encoded endolysin
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منابع مشابه
Rapid degradation of Streptococcus pyogenes biofilms by PlyC, a bacteriophage-encoded endolysin.
OBJECTIVES Streptococcus pyogenes, or Group A streptococcus (GAS), has a propensity to colonize human tissues and form biofilms. Significantly, these biofilms are a contributing mechanism of antibiotic treatment failure in streptococcal disease. In this study, we evaluate a streptococcal-specific bacteriophage-encoded endolysin (PlyC), which is known to lyse planktonic streptococci, on both sta...
متن کاملRapid degradation of Streptococcus pyogenes biofilms by PlyC, a bacteriophage-encoded endolysin
Rapid degradation of Streptococcus pyogenes biofilms by PlyC, a bacteriophage-encoded endolysin. Title Rapid degradation of Streptococcus pyogenes biofilms by PlyC, a bacteriophage-encoded endolysin. Publication Type Journal Article Year of Publication 2013 Authors Shen, Y, Köller, T, Kreikemeyer, B, Nelson, DC Journal J Antimicrob Chemother Volume 68 Issue 8 Pagination 1818-24 Date Published 2...
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The Streptococcus pyogenes transcriptional regulator Rgg controls the expression of virulence-associated genes encoded both within the core genome and within horizontally transmissible DNA such as temperate bacteriophage. Previously, we showed that Rgg binds to the non-coding DNA upstream of the bacteriophage gene encoding an extracellular DNase Spd-3. In the current study, we further character...
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PlyC, a bacteriophage-encoded endolysin, lyses Streptococcus pyogenes (Spy) on contact. Here, we demonstrate that PlyC is a potent agent for controlling intracellular Spy that often underlies refractory infections. We show that the PlyC holoenzyme, mediated by its PlyCB subunit, crosses epithelial cell membranes and clears intracellular Spy in a dose-dependent manner. Quantitative studies using...
متن کاملAbstract Title of dissertation: ENGINEERING ENHANCED STRUCTURAL STABILITY TO THE STREPTOCOCCAL BACTERIOPHAGE ENDOLYSIN PLYC
Title of dissertation: ENGINEERING ENHANCED STRUCTURAL STABILITY TO THE STREPTOCOCCAL BACTERIOPHAGE ENDOLYSIN PLYC Ryan Daniel Heselpoth, Doctor of Philosophy, 2014 Dissertation Directed by: Associate Professor Daniel C. Nelson Institute for Bioscience and Biotechnology Research and Department of Veterinary Medicine Antibiotic misuse and overuse has prompted bacteria to rapidly develop resistan...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2013
ISSN: 1460-2091,0305-7453
DOI: 10.1093/jac/dkt104